The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding (Bodrug et al 2020)
Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays (Nithianantham et al 2018)
Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble aß-tubulin pool for microtubule dynamics (Nithianantham et al 2015)
Structural Basis for the Assembly of the Mitotic motor Kinesin-5 into Bipolar Tetramers (Scholey et al 2014)
Crystal structure of TOG domains, background a C.elegans cell undergoing mitosis (Al-Bassam et al 2007)
Our research focuses on studying the molecular machines that regulate microtubule polymerization dynamics and mitotic motor mechanisms